Beaufort dropped back to .500 with a 41-19 loss on the road to Hanahan (6-2, 3-0) on Friday.
The Eagles (4-4, 1-2) have work to do to secure a playoff spot.
Connor Gruel threw a scoring pass to Elijah Thrower.
Wyatt Sherpensky (1) and Kyleik Middleton (27) had touchdowns. Sherpensky's came after a big 35-yard completion from Gruel to Will Spann.