Both southbound lanes on I-95 were blocked near the 4-mile marker for about four hours after a tractor-trailer overturned around 9:30 a.m. as rain and freezing rain worked its way through the Lowcountry.
The South Carolina Department of Public Safety announced just after 1 p.m. that the highway had been reopened.
No information on any possible injuries has been released.
The overpass at Exit 8 is also closed in both directions, according to Jasper County Emergency Services. However, drivers can still get on the entrance and exit ramps onto I-95.
Drivers are encouraged to avoid the area and, if possible, stay off the roadways.
Multiple wrecks have been reported throughout Beaufort County.
Check traffic conditions here for Beaufort County.
This story will be updated as more information becomes available.