Eric Blakely ran for four touchdowns to lead Beaufort High over Carolina Forest, 49-35, in Myrtle Beach.
The Eagles improve to 5-0 despite playing four of their first five games on the road.
"Blakely having a four-TD game is pretty good, pretty special," said Beaufort High coach Mark Clifford, who admitted he was relieved to be facing Goose Creek at home next week.
One of Blakely's touchdowns was set up by a long pass from Ben Vaigneur to tight end Stephen Baggett.
Jeffrey Tookes added a touchdown on the ground, and Kentrell Seabrook blocked a punt and returned it for a touchdown.
Defensively, Clifford said Andrew Smyth stood out, while Jonathan Hill notched three sacks.