A new Tiger Express gas station and Subway restaurant will occupy the building that once was home to the Boundary Street Sea Store.
Owner David Mixson said he purchased the building at 2265 Boundary St. in the fall and hopes to open his new convenience store, which will sell gas and diesel fuel, by late February.
The Subway is expected to open at the same time, he said.
Mixson, of Beaufort, said he owns multiple Tiger Express stations throughout South Carolina, including one on Sams Point Road on Lady's Island.
Workers are renovating the Boundary Street location, Mixson said, and will install a new car wash.
"I've been doing this for 32 years," Mixson said. "I'm just going to put my touch to it, and hopefully people will enjoy."
Mixson also owns a small building next to the convenience store, part of which he said will become an African hair-braiding salon.
The building is divided into two spaces. A Savannah woman has signed a lease to open the salon, Mixson said. It's unclear what will happen to the other side, he said.
"I've had three or four interested parties, but I haven't decided what I want to do," he said.
Other recent openings, closings and changes in the area:
Owner Bryan Loadholt said he's ready to retire and the decision to end the store's long run in Beaufort was not influenced by the economy.
"Of course, the economy is not worth a hoot, but that's not the reason I'm locking the door," said Loadholt, who has owned the business since its inception. "I'm ready to get on with my life."
Loadholt said he has not set a firm closing date but will put merchandise on sale.
Owner JoAnn Hampton said the decision to close the store at 820 D Parris Island Gateway was fueled mostly by the economy.
The store will remain open until inventory -- now on sale -- is cleared, she said.
"We have been proud to be a member of the community, and we've loved our customer base," she said.