Since Spartina 449 launched in 2009, more than 1,500 retailers worldwide have carried the designer's handbags, jewelry and accessories.
But oddly, the Hilton Head Island-based company has never had a store of its own.
On Monday, Spartina will open its first retail location, on Calhoun Street in Old Town Bluffton.
A storefront to showcase merchandise will be a boost, co-owner Kay Stanley said.
"We have retailers around the country who come here," she said. "We'll be able to show them how our products can be displayed, how things can look when they are put together."
Named after the local marsh grass and the lot number of property Stanley owns on Daufuskie Island, Spartina 449 has become recognized in the fashion industry for its vibrant patterns on scarves, bags, bracelets and more.
The company started well, doing more than $1 million in sales its first year, and has since skyrocketed.
It was ranked among the 25 fastest-growing businesses in the state for 2013 by accounting firm Scott and Co. and the investment bank The Capital Corp.
Stanley said it has averaged 100 percent growth every year, expanding its reach to boutiques in California, Hawaii and the Caribbean.
She said part of customers' attraction is the bags' unique look. Each is made with heavy linen, real leather trim and colorful patterns.
But perhaps more appealing is the link to the Lowcountry, she said.
The Calibogue collection, for example, is named for the Calibogue Sound that wraps around Daufuskie. Other collections include Shell Beach, Summer House and Sailor's Watch.
Those and other accessories will be on display at the Bluffton store.
Though business is humming along, Stanley she has no plans for any more retail locations.
"I think this is pretty much all we'll end up doing," she said. "Our primary business is wholesale."
Follow reporter Dan Burley at twitter.com/IPBG_Dan.